[C107.Ebook] Ebook Download General and Molecular Pharmacology: Principles of Drug ActionFrom Wiley

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With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention� to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.

•�� �Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students
•�� �Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs
•�� �Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties
•�� �Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development
•�� �Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides

• Sales Rank: #269825 in Books
• Published on: 2015-08-10
• Original language: English
• Number of items: 1
• Dimensions: 11.30" h x 1.30" w x 8.70" l, .0 pounds
• Binding: Hardcover
• 786 pages

From the Back Cover

Defined by ASPET as the study of the effects of chemical agents of therapeutic value or with the potential toxicity on biological systems, pharmacology is critical to understanding how drugs can correct the biochemical abnormalities responsible for human illness. It is one of the core disciplines students need to master in order to develop effective drugs and therapeutics.

This book, the updated and enhanced English translation of a successful and multi-edition Italian text, covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention mechanisms of drug action – the fundamental basis for proper clinical use - without neglecting drug interactions, general physiological functions, and the toxicological effects of chemical compounds . As opposed to classical pharmacology textbooks, which spend more time detailing medical and therapeutic effects, the authors offer thorough discussion of drug action mechanisms at cell and molecular level and the rules governing drug pharmacokinetics and development.

The target-oriented approach within the text changes the common perception of drugs as chemical entities affecting organisms and highlights the interdisciplinary and dynamic nature of pharmacological research. As such, the book introduces pharmacologists to a more integrated view of their discipline and fosters a holistic approach to the analysis and treatment of diseases – one in which drugs are regarded as critical tools to discover new cell functions, mechanisms, and therapies.

Complementary to the main text, the book has a companion website that builds on the content within the book itself by addressing more specific subjects and methodologies. The site is ideal for readers who have mastered the basic principles and are seeking more in-depth knowledge of detailed topics.

More than just a course text for pharmacology students, this book can also be a key reference and resource for researchers and professionals involved in any aspect of drug development

About the Author

Francesco Clementi is a Professor Emeritus of Pharmacology at the University of Milan. He has been President of several national and international societies and is member of the Accademia dei Lincei, the prestigious Academy of Italian Sciences. He authored over 200 publications dealing with neurotransmitter receptors and co-edited several books on neuropharmacology and cell biology including all four editions of the Italian language version of this book, Farmacologia Generale e Molecolare.

Guido Fumagalli has been the Dean of Faculty Director of the PhD School of Translational Medicine, Vice-Provost for Research, and Vice-Provost for International Affairs at the University of Verona. He has over 80 publications in international journals to his credit along with numerous books on pharmacology and sports science

Most helpful customer reviews

0 of 0 people found the following review helpful.
The book is comprehensively built in a target-oriented approach that assists the readers in better understanding the cellular an
By Hermona Soreq
I have read this most interesting textbook on General and Molecular Pharmacology with a feeling of ’this should have indeed been done, what a timely production!’. The book was put together by Guido Fumagalli and Francesco Clementi, accompanied by a very impressive cohort of co-authors and was printed in late September 2015. It differs from other books in the field in that it covers both the historical origin and the future prospects of molecular pharmacology with its links to many other fields of research, including psychology (with the enlightening contributions of Giancarlo Pepeu), biochemistry and material science. The book is comprehensively built in a target-oriented approach that assists the readers in better understanding the cellular and molecular mechanism of action of the described drugs, which immediately sheds new light on their clinical applications. It further integrates a global view of molecular pharmacology, which enables fresh understanding of the research power of drugs, viewing them as tools for in-depth discovery of new cell functions, mechanisms and well-balanced therapies. By highlighting the interdisciplinary and dynamic nature of pharmacological research, this text book integrates the essential aspects of molecular pharmacology in a printed section and also presents the most recent research achievements on each subject as a long list of electronic supplements for those interested in a deeper approach, either for professional use or as study material. Both the book and the supplements should be of great value to students of pharmacology, biotechnology and biomedical studies in general.
Guido Fumagalli and Francesco Clementi are to be congratulated on taking on this immense mission!
Hermona Soreq

0 of 0 people found the following review helpful.
I like its organization into a separate basic themes
By Amazon Customer
I am impressed by this textbook in general pharmacology. Its style is consistent throughout. The presentation of basic molecular and pharmacological concepts is clear. I like its organization into a separate basic themes, each admirably brief but to the point and up to date as far as I can tell. It is easy to find ones way around the book. The implications of basic knowledge for therapeutic interventions are well laid out, both existing ones and others under development. Limitations of current therapies are emphasized, which should help in avoiding overmedication. I congratulate the authors for a textbook that should be very useful to researchers and practioners in medical and related fields.

Terje L�mo
Professor emeritus in Physiology, University of Oslo, Norway

0 of 0 people found the following review helpful.
The text is outstanding and the coverage complete.
By S.J. Enna
The text is outstanding and the coverage complete, with a very logical and scientific approach to the subject. The volume is comprehensive while at the same time focused on elements essential for understanding drug mechanisms and clinical uses. Besides being a useful guide for medical students, this book, either in its entirety or in part, is particularly appropriate for graduate courses in pharmacology and as a reference for those actively engaged in the field.

S.J. Enna, Ph.D.
Professor of Pharmacology and of Physiology
University of Kansas Medical Center
Kansas City, Kansas USA

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[G990.Ebook] Ebook Free Shred! The Ultimate Guide to Warp Speed Guitar Book/CD, by Pete Prown, Rich Maloof

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With lessons covering more than a dozen sure-fire techniques, this book/CD combo is designed to light a fire under any player’s fingers. Shredding is difficult, but Shred! breaks it down by demystifying guitar solos that sound intimidating on record. The book is about technique first, with a fearsome roster of shred's biggest stars revealing their tricks. Each chapter tackles one killer technique in depth. Guitarists are walked through these skill sets with a hands-on approach, and are shown connections to the monster players who employ the technique. With this book, guitarists can switch gears from careful chord progressions by unleashing their inner shredder, ready to blister the paint right off the walls and annihilate any nonbelievers.

• Sales Rank: #2514887 in Books
• Brand: Brand: Backbeat Books
• Published on: 2006-05-01
• Released on: 2006-05-01
• Original language: English
• Number of items: 1
• Dimensions: 10.75" h x .31" w x 8.50" l, .67 pounds
• Binding: Sheet music
• 80 pages

Features

• Used Book in Good Condition

Most helpful customer reviews

1 of 2 people found the following review helpful.
Shred
By Eric Bourassa
This book is what is says: a guide to warp-speed guitar. It includes tips for increasing speed as well as a list of some of the greatest guitarists to grace the scene. The musical examples are fast, very fast. If you are not ready for shred, you may enjoy listening to the cd, but frustrated trying to play the examples because of their warp speed. The examples are played fast, then slow. The only problem is the slow examples sound like they are electronically slowed down versions of the fast examples, not actually played. They sound a little hokey.

20 of 21 people found the following review helpful.
A very disappointing book!!!!
By Ivan R. Hernandez Diaz
The phrase "the ultimate guide to warp speed guitar" can mislead you. First, the list of "the top 30 speed demons of rock guitar", well I guess each one of us have their favorite shredders, so is unnecessary.

Second, this is not a book that cover in detail the "surefire techniques", there's no thorough examination of each technique featured. The exercises and examples are very basic. Instead of giving you recommended discography the author could explain the aspects that makes a song representative for each chapter.

For beginners, this "book" doesn't explain the basic things to play fast like the correct position of both hands, the more efficient way to hold the pick or how to use the metronome.

"The ultimate Guide to Warp Speed Guitar" is a book that I wouldn't recommend. Troy Stetina's "Metal Guitar Tricks" and "Speed Mechanics for lead guitar" and Carl Culpepper's "Terrifying Technique for guitar" are much better books-real books, not catalogues of "impressive" techniques. If you want to really develope your technique those books are great. Also Paul Hanson's "Shred Guitar" is a very interesting book, well structured and very useful.

DON'T BUY THIS BOOK! DON'T WASTE YOUR MONEY!!

17 of 18 people found the following review helpful.
Pretty Lame...I recommend plenty of alternatives.
By Z. Miller
Upon glancing at the synopsis, this book initially sounds pretty interesting. Beyond the expected sections on alternate and sweep picking, the book offers sections on "blues shredding" and "speed riffing", which both sounded pretty cool and unusual.

However, as other reviewers have stressed, this volume simply does not deliver. It is very long on "guitar hero lore" and general descriptions of how they like to play, but very short on actual examples and licks that will help you become a better player, which I thought was the whole point.

We live in a world of limited time and resouces. If you want material that will cut to the chase and get you started improving your technique immediately, I have plenty of recommendations. Any book/DVD on this list will help you improve you technique significantly:

1. Speed Mechanics For Lead Guitar (Troy Stetina)
2. Terrifying Guitar Technique (Carl Culpepper)
3. Ultimate Guitar Technique: The Complete Guide (Bill LaFleur)
4. The "Speed Kills" Series (Michael Angelo Batio, metalmethod.com)
5. Shred Guitar Manifesto (Rusty Cooley, chopsfromhell.com)

The one from Rusty is pretty intense, so I might suggest starting with one of the others. I like the ones from Troy and Michael best, because they go into some detail about how to perform various techniques. The ones from Carl and Bill are more like "Here's a jillion exercises. Now play!" Which is useful too, because it can show you what general areas to concentrate on, but they don't go into much detail about what to focus on while practicing specific techniques.

I hope you find something of value here, and I wish you luck in becoming blazingly fast.

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[M407.Ebook] Free PDF Martes Con Mi Viejo Profesor, by Mitch Albom

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• Sales Rank: #5586439 in Books
• Published on: 2001-08
• Original language: English
• Number of items: 1
• Binding: Paperback

Most helpful customer reviews

0 of 0 people found the following review helpful.
Ayuda a caer en cuenta lo que de verdad importa.
By German
Excelentes reflexiones, de una lectura muy sencilla. No esperen gran profundidad en cada concepto pero para mi estuvo perfecto.

9 of 9 people found the following review helpful.
Morrie Schwartz -- A Teacher to the Last
By Donald Mitchell
This wonderful book focuses on the meaning of life, from the perspective of a teacher (Morrie Schwartz) who is about to lose his life and his pupil, (Mitch Albom) who has lost his focus on what is important. They come together for 14 Tuesdays (just like they did while the author was a college student at Brandeis) before the professor passes away of ALS (Lou Gehrig's disease).

This book is filed with the most beautiful sayings you can imagine. Here are a few examples: 'Giving to other people is what makes us feel alive.' 'Love each other or perish.' 'Everybody knows they are going to die, but nobody believes it. If we did, we would do things differently.' 'Learn to detach from experience.'

Many people would avoid a book on this subject, because they do not want to think about death. Although Morrie Schwartz is dying throughout this book, the subject is really about living rather than dying. Few will find the dying to be distressing, even though it is graphically and frequently addressed.

For those of us with many years to live, this book can be a wake-up call to start really living now -- in the ways we would if we were about to die, as well as to learn how to treat others while we still have them with us. For those who have but little time left, this book can be an inspiration for how to get the most out of the remaining time.

You will probably find it heart-warming (as I did) to find out that the advance on this book was paid in time to help defray some of Professor Schwartz's medical expenses.

May you find new meaning in your life from reading this wonderful book! Life is a teacher, and Morrie Schwartz's thoughts can be a text to help you understand the lessons.

2 of 2 people found the following review helpful.
es una leccion de vida
By Elena Fosman
Es una lecci�n de vida y una inrterrelacion de un viejo porofesor con su alumno que tuvo 16 a�os antes.
Una conversaci�n muy rica entre los dos a poco antes de morir su profesor, el cual le trasnsmite experiencias de su vida.

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[T667.Ebook] PDF Ebook Java: A Beginner's Tutorial, Updated for Java SE 8, by Budi Kurniawan

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• Sales Rank: #993530 in Books
• Published on: 2015-01-01
• Original language: English
• Number of items: 1
• Dimensions: 9.69" h x 1.55" w x 7.44" l, .0 pounds
• Binding: Paperback
• 720 pages

About the Author
Budi Kurniawan is known for his clear writing style. A consultant at Brainy Software Corp., he has written software licensed by Fortune 100 companies and architected and developed large scale applications for various organizations around the world. He has also published more than 100 articles in prestigious publications. His other books include the popular "How Tomcat Works" and "Servlet & JSP: A Tutorial."

Most helpful customer reviews

5 of 5 people found the following review helpful.
Beautiful work. This book is very simple to follow
By PetRaf
Beautiful work. This book is very simple to follow. But don't take it the wrong way, you will learn a lot more than the basics in java, but also what I personally like is that it teaches you the latest java technologies, and that is what you need when your starting. It also shows you how to represent the objects and it's relation in UML, which I think is a bonus. Also the order in which has been written is the more logical that I've found. For example, Generics. I bought a book on Generics that try to explain Generics first and then Collections. I started to read and give up several times. Java 8 explains first Collections then Generics and is so easy to understand that you'll learn Generics really fast! Even if you'r not new to java but want to learn the new things in java 8, this book is for you to.

2 of 2 people found the following review helpful.
Great tutorial
By William Tang
First read this book on Safari and ordered one for the Java team I'm managing. The book is good for beginners and focused on the three subjects that a beginner (and even professionals) must master: object-oriented programming, core libraries and the language itself. The structure is great, you can read from cover to cover and at the end of each chapter there is a quiz that tests the knowledge you've learned in that chapter. I feel it has been designed as a tutorial that is easy to learn and follow.

1 of 1 people found the following review helpful.
Its an excellent and clear book
By Israel Flores Cruz
Its an excellent and clear book, the author Budi Kurniawan mades the things very easy to understand , i'm very happy with this book

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Risk control, capital allocation, and realistic derivative pricing and hedging are critical concerns for major financial institutions and individual traders alike. Events from the collapse of Lehman Brothers to the Greek sovereign debt crisis demonstrate the urgent and abiding need for statistical tools adequate to measure and anticipate the amplitude of potential swings in the financial markets—from ordinary stock price and interest rate moves, to defaults, to those increasingly frequent "rare events" fashionably called black swan events. Yet many on Wall Street continue to rely on standard models based on artificially simplified assumptions that can lead to systematic (and sometimes catastrophic) underestimation of real risks.

In Practical Methods of Financial Engineering and Risk Management, Dr. Rupak Chatterjee— former director of the multi-asset quantitative research group at Citi—introduces finance professionals and advanced students to the latest concepts, tools, valuation techniques, and analytic measures being deployed by the more discerning and responsive Wall Street practitioners, on all operational scales from day trading to institutional strategy, to model and analyze more faithfully the real behavior and risk exposure of financial markets in the cold light of the post-2008 realities. Until one masters this modern skill set, one cannot allocate risk capital properly, price and hedge derivative securities realistically, or risk-manage positions from the multiple perspectives of market risk, credit risk, counterparty risk, and systemic risk.

The book assumes a working knowledge of calculus, statistics, and Excel, but it teaches techniques from statistical analysis, probability, and stochastic processes sufficient to enable the reader to calibrate probability distributions and create the simulations that are used on Wall Street to valuate various financial instruments correctly, model the risk dimensions of trading strategies, and perform the numerically intensive analysis of risk measures required by various regulatory agencies.

• Sales Rank: #178060 in Books
• Published on: 2014-08-21
• Released on: 2014-08-11
• Original language: English
• Number of items: 1
• Dimensions: 9.00" h x .88" w x 6.00" l,
• Binding: Paperback
• 388 pages

About the Author
RupakChatterjee,Ph.D., is an Industry Professor and the Deputy Director of the FinancialEngineering Division at the Stevens Institute of Technology. He is also theProgram Manager for the Accenture-Stevens Financial Services Analytics graduateprogram. Dr. Chatterjee has over fifteen years of experience as a quantitativeanalyst working for various Wall Street firms. His last role before returningto academia was as the Director of the Multi-Asset Hybrid DerivativesQuantitative Research group at Citi in New York. He was also the global BaselIII coordinator for all the modeling efforts needed to satisfy the newregulatory risk requirements. Previously, he was a quantitative analyst atBarclays Capital, a vice president at Credit Suisse, and a senior vice presidentat HSBC. His educational background is in theoretical physics, which he studiedat the University of Waterloo, Stony Brook University, and the University ofChicago. His research interests have included discrete time hedging problemsusing the Optimal Hedging Monte Carlo (OHMC) method and the design andexecution of systematic trading strategies that embody the hallmarks of capitalpreservation and measured risk-taking.

Most helpful customer reviews

9 of 10 people found the following review helpful.
A great book for both experts and amateurs in quantitative finance
By kai liang
When first time knowing this book, it was still a draft and used as notes in Professor Rupak Chatterjee’s course Financial Enterprise Risk Management. After glancing over the material, I found it containing more useful and interesting topics.
The book is as self-contained as possible: basic notions about Financial Market and Instruments are recalled in the first chapter which helps reader envision a general picture about the whole field. At the same time, combining with Bloomberg Screens and Bloomberg Functions makes all these concepts and terminologies so close to the real industry. The second chapter explains fundamental knowledge and methods in common fixed income products. Chapter 3 and chapter 4 introduced many fundamental methods which are widely used in financial files about numeric methods, statistical analysis, stochastic processes and so on. All these topics are foundation bricks for building up a financial engineering building, for example Term Structure of Statistics, Monte Carlo Simulations, Geometric Brownian Motion and Black Scholes formula. These theories are explained comprehensively and clearly in a down to earth level. It really helped me, a graduate student with electronic engineering background, attempting to be familiar with financial field.
Chapter 5 is one of the highlights of this book, which contains Professor Chatterjee’s research topic: discrete time hedging problems using the Optimal Hedging Monte Carlo (OHMC) method. One of the main goals of the OHMC method is to quantify the question of risk capital using a fully simulated P&L distribution of a hedging strategy for a derivative security. Standard option pricing methodologies ("risk neutral pricing", Black Scholes formulas) assume that dynamic hedging works perfectly and therefore the hedger has effectively replicated the option payoff with linear instruments. They make assumptions, which are largely inaccurate, of instantaneous perfect delta-hedging with no friction costs, no bid-offer spread, no transaction cost, no liquidity premium, and no hedge slippage. However, in real life delta hedging, the hedge is rarely perfect and cannot be changed continuously. Therefore, losses may occur between discrete delta hedging points. This hedge slippage needs to be quantified and this is exactly what the OHMC method provides.
Chapter 6 introduces credit derivatives including CDS, CDO and the principles behind these financial instruments. The methodology and process in which a credit product is valuated, hedged and analyzed are explained clearly including default models, survival curve with hazard rates, credit triangle and so on.
Chapter 7 covers one of the most popular topics in recent years, the risk management. In this chapter, not only the useful fundamental method and tools are introduced but also Basel II & III and their effects are explained. Knowledge of these topics is strongly essential for risk management for recent years because the regulations change frequently and strictly.
Chapter 8 and 9 introduce more advanced topics that help people working on relative fields.
I have no doubt that this book will find many interested readers from quants and graduate students in quantitative finance and it can even serve as an introduction to quantitative finance for non-specialist readers with interests in quantitative finance.

3 of 3 people found the following review helpful.
a very useful book in finance field
By lxx
I am a professional student in Financial Engineering. This book largely helps me improve my knowledge system in financial engineering. The book details the forefront knowledge and the latest trends on Wall Street, especially for lots of practical mathematical modeling. I think this book is “the Bible” in the finance field.

3 of 3 people found the following review helpful.
Five Stars
By Kuan-Heng Chen
Great book. It is very useful book for both academic and industrial fields.

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• Sales Rank: #268671 in Books
• Published on: 2016
• Binding: Paperback

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0 of 0 people found the following review helpful.
Five Stars
By Amazon Customer
This book is a good book to self-study!!

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A real-world guide to success in construction estimating, the DEWALT Construction Estimating Handbook is loaded with tips, checklists, worksheets, data tables, and tutorials that will provide readers with the tools they need to effectively navigate through every step of the estimating process. The book focuses on the construction estimating "how-to" essentials and provides on-the-spot answers backed up with graphic examples. With a thorough understanding of the important profit-making factors within the industry, its comprehensive coverage includes marketing, bid planning, scope review, quantity take-off for all trades and divisions, cost analysis, value engineering, Excel spreadsheet estimating, and more. Based on the author's extensive experience in estimating, this valuable resource aims to provide workable solutions to the unprecedented challenges that construction professionals face today, from a weak economy and fierce competition to material price volatilities, skilled labor shortages, and strict regulations.
Key Handbook Features

• All the preprogrammed Excel templates referenced in the book plus more are available for free download at the DEWALT/Cengage website.
• Addresses steps of the bidding process applicable for residential and industrial/commercial construction projects.
• Comprehensive format providing theory, how-to and step-by-step instructions, real-world examples, and technical reference data resulting in an all-inclusive resource.

• Sales Rank: #369598 in Books
• Brand: Brand: Cengage Learning, DEWALT
• Model: 978-1-4354-9899
• Published on: 2009-12-04
• Original language: English
• Number of items: 1
• Dimensions: 10.25" h x 8.00" w x .75" l, 1.14 pounds
• Binding: Paperback
• 352 pages

Features

• Used Book in Good Condition

About the Author
Adam Ding, M.Sc., PQS, GSC, PMP, CC, LEED AP (BD+C), is a professional estimator with extensive experience in a variety of commercial, institutional, industrial, residential, heavy/civil, and sustainable infrastructure projects. He holds a master's degree in building construction from Auburn University, a professional quantity surveying diploma from the Canadian Institute of Quantity Surveyors, a project management professional certificate from the Project Management Institute, a gold seal certificate in estimating from the Canadian Construction Association, a competent communicator certificate from Toastmaster International, and a LEED accredited professional certificate from the Green Building Certification Institute. Adam has enjoyed a successful career estimating projects of varied sizes, ranging from large-scale cost planning to detailed trade take-off. Having bid countless construction projects, he developed a unique and easy-to-understand estimating approach. He has also taught classes at Auburn University and owns the copyrights for a number of spreadsheet estimating programs. Adam currently teaches in the construction management degree program at Red River College. He is a regular contributor to Construction Economist journal, introducing the latest estimating technologies and techniques. Interested readers can also check out Adam's other popular estimating books: DEWALT CONSTRUCTION ESTIMATING PROFESSIONAL REFERENCE, DEWALT PLUMBING ESTIMATING PROFESSIONAL REFERENCE, and DEWALT ELECTRICAL ESTIMATING PROFESSIONAL REFERENCE, Second Edition.

American Contractors Educational Services has successfully prepared candidates for state required licensing exams since 1991. A team of full time instructors comprises field experience, training expertise and formal education to formulate an effective and dynamic approach to concisely present pertinent test information in a seminar format.

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9 of 9 people found the following review helpful.
Bait and Ignore
By Hope It Helps
Bought the first edition specifically because the cover said that the forms were available for download. The second does not. There are references all over the book where to go on the DeWalt site to download the forms. The forms are not there. Set up an account and contacted DeWalt about forms. No reply. Did some more searching and found that DeWalt has another book called Contractor's Forms and Letters that comes with a CD. Companion to the second edition of Construction Estimating? The book is just about useless without the forms since you would have to spend a lot of time recreating what you need.

0 of 0 people found the following review helpful.
Five Stars
By AGAO
EXCELLENT

0 of 0 people found the following review helpful.
Full of very useful information.
By C. Miller
Very handy. Full of very useful information.

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DEWALT Construction Estimating Complete Handbook (DEWALT Series), by Adam Ding, American Contractors Educational Services PDF
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DEWALT Construction Estimating Complete Handbook (DEWALT Series), by Adam Ding, American Contractors Educational Services PDF

DEWALT Construction Estimating Complete Handbook (DEWALT Series), by Adam Ding, American Contractors Educational Services PDF

DEWALT Construction Estimating Complete Handbook (DEWALT Series), by Adam Ding, American Contractors Educational Services PDF

DEWALT Construction Estimating Complete Handbook (DEWALT Series), by Adam Ding, American Contractors Educational Services PDF